ACTH (4-7) Pro-Gly-Pro
Also known as: ACTH (4-7) Pro-Gly-Pro, Semax precursor
A heptapeptide consisting of the ACTH 4-7 fragment extended with a Pro-Gly-Pro tail, better known as the peptide Semax. It is studied as a nootropic and neuroprotective agent.
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Mechanism of Action
This peptide corresponds to Semax, in which the C-terminal Pro-Gly-Pro motif markedly slows enzymatic degradation of the active ACTH(4-7) core. It has no corticotropic (steroidogenic) activity but retains the neurotropic effects of melanocortin fragments. It is reported to increase expression of BDNF and its receptor TrkB in the hippocampus and to modulate dopaminergic and serotonergic systems. These actions are associated with enhanced learning, attention and neuroprotection in animal and human studies.
- Half-life
- Short; minutes for the parent peptide, extended versus unmodified ACTH(4-7)
- Administration Routes
- intranasal
- Research Status
- Research Chemical
Reported Benefits
- Studied to enhance attention, memory and learning
- Reported neuroprotective effects in ischemia models
- Upregulation of BDNF and TrkB signaling
- Investigated for stress resilience and mood
- Lacks the hormonal corticotropic activity of full ACTH
Potential Side Effects
- Mild nasal irritation with intranasal use
- Headache
- Transient changes in alertness
- Rarely reported irritability
Common Dosing
Research and clinical literature on Semax commonly references intranasal dosing in the low microgram-to-milligram range per day; exact regimens vary by formulation. Provided for research-use-only context and not as personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding due to limited data
- Known hypersensitivity to the peptide
- Acute psychiatric instability
N-Acetyl Semax Amidate
N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.
N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a stabilized analog of the anxiolytic peptide Selank, modified for improved durability and intranasal delivery. It is studied for anxiety reduction and cognitive support.
N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.
Noopept
A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.
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Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
2006
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Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
2020
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[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]
2018
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Effects of Semax on the Default Mode Network of the Brain
2018