Noopept
Also known as: Noopept, N-phenylacetyl-L-prolylglycine ethyl ester
A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.
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Mechanism of Action
Noopept is metabolized in part to cycloprolylglycine, an endogenous neuropeptide that modulates AMPA and NMDA glutamate receptor signaling. It is reported to increase expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus. Additional proposed actions include antioxidant activity and inhibition of glutamate excitotoxicity. These mechanisms are thought to underlie its reported memory-consolidation and neuroprotective effects in animal models.
- Half-life
- Roughly 30-60 minutes for the parent compound
- Administration Routes
- oral, intranasal
- Research Status
- Research Chemical
Reported Benefits
- Studied to support memory formation and recall
- May enhance learning and cognitive processing
- Reported neuroprotective and antioxidant activity
- Upregulation of BDNF and NGF in animal studies
- Active at very low milligram doses
- Investigated for mood and anxiety modulation
Potential Side Effects
- Headache, sometimes reduced by adding a choline source
- Irritability or restlessness
- Fatigue or brain fog at higher doses
- Sleep disturbance
Common Dosing
Research literature commonly references oral doses of 10-30 mg per day, often split into two or three administrations. Provided for research-use-only context and not as personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding due to insufficient safety data
- Known hypersensitivity to the compound
- Caution with other CNS-active drugs
N-Acetyl Semax Amidate
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N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a stabilized analog of the anxiolytic peptide Selank, modified for improved durability and intranasal delivery. It is studied for anxiety reduction and cognitive support.
N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.
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Noopept stimulates the expression of NGF and BDNF in rat hippocampus
2008
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Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin
2009
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The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model
2007
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GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons
2003