Is Noopept a racetam?

It is structurally related to the racetam family but is technically a proline-containing dipeptide derivative; it is often grouped with racetams because of similar reported effects.

Why are the doses so small?

Noopept is reported to be far more potent by weight than piracetam, so research doses are typically in the low tens of milligrams rather than grams.

Why do people pair it with choline?

Some users report that adding a choline source helps reduce headaches that can accompany cholinergic-active nootropics, though this is anecdotal.

← All peptides

Cognitive & Nootropic

Research Chemical

Noopept

Also known as: Noopept, N-phenylacetyl-L-prolylglycine ethyl ester

A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.

Mechanism of Action

Noopept is metabolized in part to cycloprolylglycine, an endogenous neuropeptide that modulates AMPA and NMDA glutamate receptor signaling. It is reported to increase expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus. Additional proposed actions include antioxidant activity and inhibition of glutamate excitotoxicity. These mechanisms are thought to underlie its reported memory-consolidation and neuroprotective effects in animal models.

Half-life: Roughly 30-60 minutes for the parent compound
Administration Routes: oral, intranasal
Research Status: Research Chemical