N-Acetyl Semax Amidate
Also known as: N-Acetyl Semax Amidate, NASA peptide, NA-Semax-Amidate
N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.
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Mechanism of Action
N-Acetyl Semax Amidate is an analog of the ACTH(4-10) fragment Semax in which N-acetylation and C-terminal amidation enhance stability against peptidases. It strongly upregulates brain-derived neurotrophic factor (BDNF) and its receptor TrkB, supporting neuroplasticity, neuronal survival, and synaptic function. Semax analogs also modulate the dopaminergic and serotonergic systems and inhibit enkephalin-degrading enzymes, contributing to improved focus, motivation, and stress resilience. These combined neurotrophic and neuromodulatory actions underlie its investigated nootropic and neuroprotective effects, including in ischemic models.
- Half-life
- Extended versus native Semax due to acetylation and amidation, on the order of hours
- Administration Routes
- intranasal
- Research Status
- Research Chemical
Reported Benefits
- Upregulates BDNF and supports neuroplasticity
- May enhance focus, memory, and learning in study models
- Investigated for neuroprotection in ischemic and stress conditions
- Supports motivation and mental energy
- Modulates dopaminergic and serotonergic tone
- Convenient intranasal delivery
Potential Side Effects
- Nasal irritation or congestion with intranasal use
- Possible overstimulation or restlessness
- Transient headache
- Unknown long-term safety in humans outside Russian research
Common Dosing
For research use only and not personal medical advice: protocols commonly reference 250-600 mcg per intranasal administration one or more times daily across study designs. Not approved for human use in most jurisdictions.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity to the peptide
- Severe anxiety disorders where stimulation may worsen symptoms
N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a stabilized analog of the anxiolytic peptide Selank, modified for improved durability and intranasal delivery. It is studied for anxiety reduction and cognitive support.
N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.
Noopept
A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.
P21 (P021)
P21 (P021) is a small peptidergic compound derived from the active region of ciliary neurotrophic factor, studied for promoting neurogenesis and synaptic plasticity. It is researched preclinically as a neuroprotective and cognition-enhancing agent.
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Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties
2016
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Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain
2006
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Effects of Semax on the Default Mode Network of the Brain
2018
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[Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke]
1999