What is Semax derived from?

Semax is based on a fragment of the hormone ACTH (specifically ACTH 4-10), modified so it carries the nootropic and neuroprotective actions without the hormonal effects of the parent molecule.

How does the acetyl-amidate version differ from plain Semax?

The N-acetyl and C-terminal amide modifications protect the peptide from rapid enzymatic breakdown, extending its duration and making it better suited to intranasal delivery.

Is N-Acetyl Semax Amidate approved for human use?

It is approved as a medicine in Russia but remains an unapproved research compound in most countries and should only be handled in laboratory research contexts.

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Cognitive & Nootropic

Healing & Recovery

Research Chemical

N-Acetyl Semax Amidate

Also known as: N-Acetyl Semax Amidate, N-Acetyl Semax

N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.

Mechanism of Action

N-Acetyl Semax Amidate is an analog of the ACTH(4-10) fragment Semax in which N-acetylation and C-terminal amidation enhance stability against peptidases. It strongly upregulates brain-derived neurotrophic factor (BDNF) and its receptor TrkB, supporting neuroplasticity, neuronal survival, and synaptic function. Semax analogs also modulate the dopaminergic and serotonergic systems and inhibit enkephalin-degrading enzymes, contributing to improved focus, motivation, and stress resilience. These combined neurotrophic and neuromodulatory actions underlie its investigated nootropic and neuroprotective effects, including in ischemic models.

Half-life: Extended versus native Semax due to acetylation and amidation, on the order of hours
Administration Routes: intranasal
Research Status: Research Chemical