N-Acetyl Selank Amidate
Also known as: N-Acetyl Selank Amidate, NASA-Selank, NA-Selank-Amidate
N-Acetyl Selank Amidate is a stabilized analog of the anxiolytic peptide Selank, modified for improved durability and intranasal delivery. It is studied for anxiety reduction and cognitive support.
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Mechanism of Action
N-Acetyl Selank Amidate is a Tuftsin-derived heptapeptide analog in which N-terminal acetylation and C-terminal amidation increase resistance to enzymatic degradation. It modulates the GABAergic and serotonergic systems and influences the expression and metabolism of enkephalins, producing anxiolytic effects without sedation or dependence. Selank analogs also raise brain-derived neurotrophic factor (BDNF) and modulate the balance of pro- and anti-inflammatory cytokines, linking its nootropic and immune-modulating actions. The stabilizing modifications support its use via intranasal administration for central nervous system access.
- Half-life
- Extended versus native Selank due to acetylation and amidation, on the order of hours
- Administration Routes
- intranasal
- Research Status
- Research Chemical
Reported Benefits
- Reduces anxiety without sedation in study models
- Non-addictive anxiolytic profile
- May improve attention, memory, and mental clarity
- Modulates cytokine balance with immune-supportive effects
- Influences BDNF and neuroplasticity pathways
- Convenient intranasal delivery
Potential Side Effects
- Nasal irritation or congestion with intranasal use
- Mild fatigue or drowsiness in some users
- Transient headache
- Unknown long-term safety in humans outside Russian research
Common Dosing
For research use only and not personal medical advice: protocols commonly reference 250-500 mcg per intranasal administration one or more times daily across study designs. Not approved for human use in most jurisdictions.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity to the peptide
- Concurrent strong sedatives without clinician oversight
N-Acetyl Semax Amidate
N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.
N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.
DSIP
Delta Sleep-Inducing Peptide is a small neuromodulatory nonapeptide studied for its effects on sleep architecture, stress hormones, and pain modulation.
Noopept
A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.
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[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]
2008
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[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]
2014
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Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
2018
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The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action
2014