What does each peptide in this blend do?

N-Acetyl Semax is studied mainly as a nootropic that boosts focus and BDNF, while N-Acetyl Selank is studied as an anxiolytic that modulates GABA and serotonin without sedation.

What do N-acetyl and amidate mean?

They are chemical modifications to the peptide termini that protect against enzymatic breakdown, increasing stability and duration compared with the unmodified versions.

Is this blend approved as a medication?

Semax and Selank are used clinically in Russia, but neither is FDA-approved; the blend is sold for research purposes only.

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Cognitive & Nootropic

Research Chemical

N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend

Also known as: N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend

A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.

Mechanism of Action

Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulates the dopaminergic and serotonergic systems, and inhibits enkephalin-degrading enzymes to extend endogenous neuropeptide activity. Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin that modulates GABAergic and serotonergic tone, alters expression of interleukins and BDNF, and produces anxiolytic effects without sedation. The N-acetyl and amidate modifications protect both peptides from peptidase degradation, improving stability for intranasal delivery, and the blend pairs cognitive enhancement with stress reduction.

Half-life: Short for both parent peptides (minutes); the N-acetyl and amidate modifications extend duration of action to several hours.
Administration Routes: intranasal, subcutaneous
Research Status: Research Chemical