N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
Also known as: N-Acetyl Semax Amidate / N-Acetyl Selank Amidate Blend
A research blend of two stabilized Russian-developed neuropeptides: N-Acetyl Semax (a nootropic ACTH fragment) and N-Acetyl Selank (an anxiolytic tuftsin analog). The combination is studied for cognition, focus, and stress modulation.
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Mechanism of Action
Semax is a synthetic analog of ACTH(4-10) that increases brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulates the dopaminergic and serotonergic systems, and inhibits enkephalin-degrading enzymes to extend endogenous neuropeptide activity. Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin that modulates GABAergic and serotonergic tone, alters expression of interleukins and BDNF, and produces anxiolytic effects without sedation. The N-acetyl and amidate modifications protect both peptides from peptidase degradation, improving stability for intranasal delivery, and the blend pairs cognitive enhancement with stress reduction.
- Half-life
- Short for both parent peptides (minutes); the N-acetyl and amidate modifications extend duration of action to several hours.
- Administration Routes
- intranasal, subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Studied for enhanced focus, memory, and learning
- May reduce anxiety without sedation
- Explored for increased BDNF and neurotrophic support
- Investigated for improved stress resilience and mood
- Combines nootropic and anxiolytic peptide actions
- Stabilized forms intended for intranasal absorption
Potential Side Effects
- Nasal irritation or congestion with intranasal use
- Mild headache
- Fatigue or overstimulation in some users
- Unknown effects from combining peptides
- Limited long-term human safety data
Common Dosing
For research use only and not medical advice; literature describes intranasal Semax and Selank in the ~250-900 mcg per dose range one to three times daily for the individual peptides. The blend has no standardized protocol and varies by vendor.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known hypersensitivity to either peptide
- Caution with other serotonergic or CNS-active agents
N-Acetyl Semax Amidate
N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.
N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a stabilized analog of the anxiolytic peptide Selank, modified for improved durability and intranasal delivery. It is studied for anxiety reduction and cognitive support.
Semax
A synthetic peptide derived from ACTH(4-10) developed in Russia and used there for cognitive enhancement, stroke recovery, and neuroprotection. Often used intranasally.
Selank
A synthetic analog of the immunomodulatory peptide tuftsin developed in Russia for anxiety reduction and cognitive support without the sedation or dependence of benzodiazepines.
Noopept
A synthetic dipeptide-derived nootropic developed in Russia, structurally related to the racetam family. It is studied for memory, learning and neuroprotective effects at very low milligram doses.
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Functional Connectomic Approach to Studying Selank and Semax Effects
2020
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Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
2006
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[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]
2014
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Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
2017