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Also known as: SNAP-8, Acetyl Octapeptide-3
SNAP-8 (Acetyl Octapeptide-3) is a topical cosmetic peptide marketed as a needle-free alternative for softening expression lines by reducing muscle contraction at the surface. It is an elongated analog of the Argireline hexapeptide.
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SNAP-8 is Acetyl Octapeptide-3, an eight-amino-acid peptide derived from the N-terminus of SNAP-25. It is designed to compete with native SNAP-25 within the SNARE protein complex required for neurotransmitter vesicle docking and fusion at the neuromuscular junction. By interfering with SNARE complex assembly, it is theorized to reduce acetylcholine release and thereby attenuate the strength of facial muscle contractions that produce dynamic expression lines. Applied topically, the effect is local and reversible, in contrast to the enzymatic cleavage produced by botulinum toxin, and it is frequently formulated alongside Argireline (Acetyl Hexapeptide-3/8).