Syn-AKE
Also known as: Syn-AKE, Syn-Ake, Dipeptide Diaminobutyroyl Benzylamide Diacetate
Syn-AKE is a topical synthetic dipeptide inspired by snake venom, used in cosmetics to relax facial muscles and soften expression lines.
Last updated
Mechanism of Action
Syn-AKE (dipeptide diaminobutyroyl benzylamide diacetate) is a synthetic mimic of waglerin-1, a peptide from temple viper venom. It acts as a reversible antagonist of the muscle-type nicotinic acetylcholine receptor (mnAChR) at the neuromuscular junction. By blocking acetylcholine from binding, it keeps muscle fibers in a more relaxed state, reducing the repetitive contractions that form dynamic wrinkles. The effect is topical and reversible, producing a smoothing of expression lines without injection.
- Half-life
- Not applicable systemically; acts locally in topical use
- Administration Routes
- topical
- Research Status
- Research Chemical
Reported Benefits
- Reduces the appearance of dynamic wrinkles
- Topical, needle-free muscle-relaxing concept
- Smooths forehead and around-eye lines
- Compatible with other cosmetic peptides
- Generally well tolerated on skin
Potential Side Effects
- Mild redness or tingling
- Possible dryness with frequent use
- Rare sensitivity to formulation ingredients
Common Dosing
For research purposes only: typically formulated at roughly 1-4 percent of supplier solution in topical serums or creams, applied once or twice daily. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known allergy to the peptide or carrier ingredients
- Application to broken or irritated skin
Acetyl Hexapeptide-3 (Argireline)
Argireline is a topical cosmetic peptide marketed as a needle-free alternative to neuromodulators, used to soften the appearance of expression lines.
SNAP-8
SNAP-8 (Acetyl Octapeptide-3) is a topical cosmetic peptide marketed as a needle-free alternative for softening expression lines by reducing muscle contraction at the surface. It is an elongated analog of the Argireline hexapeptide.
Matrixyl
Matrixyl is a palmitoylated pentapeptide (Pal-KTTKS) used topically to stimulate collagen and extracellular matrix synthesis. It is a widely studied cosmetic anti-wrinkle peptide.
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Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests
2024
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Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy
2020
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The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.
2026
Note: Tested in a multi-ingredient product, so the result can't be attributed to Syn-AKE alone.