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Also known as: Syn-AKE, Syn-Ake, Dipeptide Diaminobutyroyl Benzylamide Diacetate
Syn-AKE is a topical synthetic dipeptide inspired by snake venom, used in cosmetics to relax facial muscles and soften expression lines.
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Syn-AKE (dipeptide diaminobutyroyl benzylamide diacetate) is a synthetic mimic of waglerin-1, a peptide from temple viper venom. It acts as a reversible antagonist of the muscle-type nicotinic acetylcholine receptor (mnAChR) at the neuromuscular junction. By blocking acetylcholine from binding, it keeps muscle fibers in a more relaxed state, reducing the repetitive contractions that form dynamic wrinkles. The effect is topical and reversible, producing a smoothing of expression lines without injection.