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Also known as: Palmitoyl Dipeptide-6
Palmitoyl Dipeptide-6 is a lipidated cosmetic dipeptide used in topical anti-aging formulations. It is marketed for supporting skin firmness and a smoother, more youthful appearance.
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Palmitoyl Dipeptide-6 conjugates a short dipeptide sequence to a palmitic acid chain, increasing lipophilicity to improve delivery across the stratum corneum. As a signal peptide it is intended to interact with dermal fibroblasts to encourage extracellular matrix protein expression and support collagen network integrity. By acting on cellular signaling rather than as an inert moisturizer, it is positioned as a biofunctional ingredient that helps maintain dermal structure.