What is the difference between Pal-GHK and GHK-Cu?

Pal-GHK is the GHK tripeptide with a palmitoyl lipid tail for better skin penetration, while GHK-Cu is the GHK peptide bound to a copper ion. Both support collagen, but they differ in delivery and the role of copper.

Is Pal-GHK applied topically or injected?

Pal-GHK is formulated for topical application in skincare products. The palmitoyl chain is specifically designed to help it penetrate the skin barrier when applied to the surface.

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Collagen & Skin

Research Chemical

Pal-GHK (Palmitoyl Tripeptide-1)

Also known as: Pal-GHK, PAL-GHK, Palmitoyl Tripeptide-1

Pal-GHK (Palmitoyl Tripeptide-1) is a lipidated derivative of the well-known GHK matrikine, engineered with a palmitic acid tail to enhance skin penetration. It is widely used in topical anti-aging and collagen-boosting cosmetics.

Mechanism of Action

Pal-GHK couples the glycyl-histidyl-lysine (GHK) tripeptide to a palmitoyl chain, improving lipophilicity and transdermal delivery. The GHK matrikine acts as a messenger signal that upregulates collagen, elastin, and glycosaminoglycan synthesis by dermal fibroblasts and modulates expression of remodeling genes. It also influences metalloproteinase activity and supports extracellular matrix repair, contributing to firmer, smoother skin.

Half-life: Not formally established; functions locally in the dermis after topical use
Administration Routes: topical
Research Status: Research Chemical