Loading peptide…
PeptideChat is for educational and research purposes only. Nothing on this site constitutes medical advice. Peptides are sold as research chemicals only and are not intended for human use. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. PeptideChat is an independent educational resource — not a pharmacy, compounding, or 503A/503B outsourcing facility — and does not sell products or provide medical advice.
Also known as: P21, P021
P21 (P021) is a small peptidergic compound derived from the active region of ciliary neurotrophic factor, studied for promoting neurogenesis and synaptic plasticity. It is researched preclinically as a neuroprotective and cognition-enhancing agent.
Sign in to rate this peptide.
P21 is a tetrapeptide mimetic engineered from the biologically active site of ciliary neurotrophic factor (CNTF), modified with adamantylation to improve stability and blood-brain-barrier penetration. It enhances brain-derived neurotrophic factor (BDNF) signaling through the TrkB receptor, promoting hippocampal neurogenesis and dendritic spine density. In animal models it also inhibits abnormal tau hyperphosphorylation and reduces neuroinflammatory and amyloid-related pathology.