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Also known as: Semax
A synthetic peptide derived from ACTH(4-10) developed in Russia and used there for cognitive enhancement, stroke recovery, and neuroprotection. Often used intranasally.
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Semax is a heptapeptide analog of ACTH(4-10) that lacks corticotropic activity but exerts strong neurotropic effects. It increases brain-derived neurotrophic factor (BDNF) and its receptor TrkB, modulates dopaminergic and serotonergic systems, and influences the expression of genes related to neuroplasticity. It also inhibits enkephalin-degrading enzymes, raising endogenous regulatory peptide levels.