Dihexa
Also known as: Dihexa, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A small-molecule angiotensin IV analog studied for potent procognitive and synaptogenic effects, reported in preclinical work to be orders of magnitude more potent than BDNF at forming synapses.
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Mechanism of Action
Dihexa is an orally active, blood-brain-barrier-penetrant angiotensin IV analog that acts on the hepatocyte growth factor (HGF)/c-Met receptor system. By potentiating HGF/c-Met signaling, it promotes synaptogenesis and dendritic spine formation in the hippocampus. Preclinical research reports it facilitates new functional synapse formation at extremely low concentrations, underlying its interest for memory and neurodegenerative models.
- Half-life
- Not well characterized in humans
- Administration Routes
- oral, topical
- Research Status
- Preclinical
Reported Benefits
- Potent synaptogenesis in preclinical models
- Orally active and BBB-penetrant
- Studied for memory enhancement and learning
- Investigated in models of Alzheimer's and Parkinson's
- Active at very low concentrations
Potential Side Effects
- Very limited human safety data
- Theoretical concern: HGF/c-Met activity and cancer pathways
- Possible overstimulation (anecdotal)
- Purity and dosing uncertainty as a research chemical
Common Dosing
Preclinical and anecdotal references cite ~5-20 mg per day orally or transdermally; human data is lacking. Educational reference only, not advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active or suspected malignancy (c-Met pathway)
- Pregnancy or breastfeeding
- Not approved for human use; minimal safety data
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AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
2021
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Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
2024
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Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies
2021
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The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases
2015
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Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.
2015