Selank
Also known as: Selank
A synthetic analog of the immunomodulatory peptide tuftsin developed in Russia for anxiety reduction and cognitive support without the sedation or dependence of benzodiazepines.
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Mechanism of Action
Selank is a heptapeptide derived from tuftsin that modulates the balance of monoamines and increases expression of BDNF in the hippocampus. It influences GABAergic and serotonergic signaling, producing anxiolytic effects without sedation, and stabilizes enkephalins by inhibiting their breakdown. It also has documented immunomodulatory activity, reflecting its tuftsin origin.
- Half-life
- Short in plasma; central effects persist several hours
- Administration Routes
- intranasal, subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Anxiolytic effects without sedation or dependence
- May improve focus and mental clarity
- Increases BDNF and supports neuroplasticity
- Immunomodulatory activity
- Studied as a benzodiazepine alternative in Russia
Potential Side Effects
- Mild nasal irritation (intranasal use)
- Occasional fatigue or lightheadedness
- Limited Western clinical data
- Rare paradoxical restlessness
Common Dosing
Research and Russian clinical references cite ~250-900 mcg per day intranasally, often divided. Educational range only.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy or breastfeeding
- Not approved outside of certain countries
- Hypersensitivity to the peptide
Semax
A synthetic peptide derived from ACTH(4-10) developed in Russia and used there for cognitive enhancement, stroke recovery, and neuroprotection. Often used intranasally.
PE-22-28
A spadin-derived peptide studied as a fast-acting antidepressant candidate that works by blocking the TREK-1 potassium channel, with reported neurogenic and neuroprotective effects.
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[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]
2008
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[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]
2014
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Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
2019
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Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
2018