What is a senotherapeutic peptide?

It is a compound designed to act on senescent (aged, non-dividing) cells, either clearing them or dampening their harmful inflammatory secretions, which OS-01 does within the skin to slow visible aging.

How is OS-01 applied?

OS-01 is formulated for topical use, applied to the skin as part of a serum so its effects are concentrated locally rather than acting systemically.

Is OS-01 the same as Pro-Xylane?

It is listed with the alias Pro-Xylane by some vendors, but OS-01 is specifically marketed as a senotherapeutic skin peptide, and buyers should verify the exact ingredient identity with the supplier.

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Collagen & Skin

Longevity & Anti-aging

Research Chemical

OS-01

Also known as: OS-01, Peptide 14, OneSkin peptide

OS-01 is a senotherapeutic peptide developed for topical skin application that targets cellular senescence to improve skin aging markers. It is studied for reducing senescent-cell burden and supporting youthful skin function.

Mechanism of Action

OS-01 is a synthetic peptide identified through machine-learning screening to act as a partial senotherapeutic, modulating the activity of senescent skin cells rather than killing them outright. By influencing signaling pathways associated with the senescence-associated secretory phenotype (SASP), it aims to reduce the pro-inflammatory secretions that degrade the dermal matrix and accelerate visible aging. Topical application targets keratinocytes and fibroblasts to restore more youthful gene-expression patterns linked to barrier function and collagen support. The result studied is improved skin texture, hydration, and resilience associated with lowered senescent-cell burden.

Half-life: Not well characterized for systemic exposure; acts locally at the application site
Administration Routes: topical
Research Status: Research Chemical