OS-01
Also known as: OS-01, Peptide 14, OneSkin peptide
OS-01 is a senotherapeutic peptide developed for topical skin application that targets cellular senescence to improve skin aging markers. It is studied for reducing senescent-cell burden and supporting youthful skin function.
Last updated
Mechanism of Action
OS-01 is a synthetic peptide identified through machine-learning screening to act as a partial senotherapeutic, modulating the activity of senescent skin cells rather than killing them outright. By influencing signaling pathways associated with the senescence-associated secretory phenotype (SASP), it aims to reduce the pro-inflammatory secretions that degrade the dermal matrix and accelerate visible aging. Topical application targets keratinocytes and fibroblasts to restore more youthful gene-expression patterns linked to barrier function and collagen support. The result studied is improved skin texture, hydration, and resilience associated with lowered senescent-cell burden.
- Half-life
- Not well characterized for systemic exposure; acts locally at the application site
- Administration Routes
- topical
- Research Status
- Research Chemical
Reported Benefits
- Targets senescent skin cells to reduce SASP-driven inflammation
- Studied for improved skin texture and smoothness
- May support dermal collagen and barrier function
- Investigated for reduced fine lines and improved firmness
- Topical delivery localizes effects to skin
- Explored as a senotherapeutic anti-aging approach
Potential Side Effects
- Mild skin irritation or redness at application site
- Possible dryness or transient sensitivity
- Rare contact allergic reaction
- Limited independent long-term human data
Common Dosing
For research and informational reference only and not personal medical advice: studied as a topical serum applied to the skin once or twice daily at low peptide concentrations per formulation. Follow product or study formulation guidance.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known hypersensitivity to the peptide or formulation excipients
- Application to broken or actively inflamed skin
- Use around eyes or mucous membranes unless formulated for it
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Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
2023
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Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation
2024
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Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging
2025
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In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14
2022
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OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial.
2025