MIF-1
Also known as: MIF-1, Melanocyte-Inhibiting Factor-1, PLG
MIF-1 (Pro-Leu-Gly-NH2) is a hypothalamic tripeptide studied for dopaminergic modulation and antidepressant-like effects. It is also known historically as melanocyte-inhibiting factor.
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Mechanism of Action
MIF-1 is a tripeptide (Pro-Leu-Gly-NH2) derived from oxytocin that acts as an allosteric modulator of central dopamine receptors, enhancing dopaminergic transmission. It is reported to potentiate dopamine receptor sensitivity and influence neuropeptide signaling without directly activating the receptor. Through these actions it shows antidepressant-like and anti-parkinsonian effects in experimental models. It was originally characterized for inhibiting release of melanocyte-stimulating hormone from the pituitary.
- Half-life
- Short, on the order of minutes for the free tripeptide
- Administration Routes
- subcutaneous, intranasal
- Research Status
- Research Chemical
Reported Benefits
- Modulates central dopaminergic signaling
- Antidepressant-like effects in animal models
- Investigated for anti-parkinsonian activity
- May enhance dopamine receptor sensitivity
- Studied for neuroprotective potential
Potential Side Effects
- Limited human safety data
- Possible transient mood or sleep changes
- Injection-site irritation
- Unknown long-term effects
Common Dosing
For research use only: experimental literature references microgram-to-milligram-range research dosing in animal and exploratory settings; no validated human dosing exists. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Active psychiatric instability without oversight
- Known peptide hypersensitivity
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Improvement in major depression after low subcutaneous doses of MIF-1
1994
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Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression
1978
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Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog
2005
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From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides
2007