How is HGH Fragment 176-191 different from full growth hormone?

It is only the small C-terminal piece of GH responsible for fat metabolism. It retains lipolytic activity but lacks the regions that drive growth, IGF-1 elevation, and the glucose effects of full-length GH.

Is it related to AOD9604?

Yes. AOD9604 is a modified, tyrosine-stabilized version of the 176-191 fragment developed to improve stability while retaining the fat-loss activity studied for this region of GH.

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Weight & Metabolic

Research Chemical

HGH Fragment 176-191

Also known as: HGH Fragment 176-191, hGH Fragment 176-191, Fragment 176-191, Frag 176-191, HGH Frag

HGH Fragment 176-191 is the C-terminal fragment of human growth hormone studied primarily for its fat-reducing effects without the broader growth-promoting actions of full-length GH. It is a popular research compound for lipolysis.

Mechanism of Action

The fragment corresponds to amino acids 176 to 191 of human growth hormone, the region associated with GH's lipolytic activity. In animal models it stimulates lipolysis (fat breakdown) and inhibits lipogenesis, apparently by acting on adipose tissue beta-3 adrenergic signaling and modulating fatty acid metabolism. Because it lacks the residues responsible for GH's effects on growth and insulin resistance, it is reported not to meaningfully raise IGF-1 or blood glucose.

Half-life: Short; on the order of 20 to 30 minutes
Administration Routes: subcutaneous
Research Status: Research Chemical