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Also known as: Tesamorelin, Egrifta
A stabilized GHRH analog FDA-approved to reduce excess visceral abdominal fat in HIV-associated lipodystrophy. Studied for its strong effect on visceral adipose tissue.
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Tesamorelin is a synthetic analog of human GHRH stabilized against enzymatic degradation, binding pituitary GHRH receptors to increase endogenous GH and IGF-1. The resulting GH elevation enhances lipolysis, with a particularly pronounced effect on visceral adipose tissue. It preserves pulsatile GH release while achieving clinically meaningful reductions in deep abdominal fat.