Why combine CJC-1295 (no DAC) with GHRP-2?

They act on two different receptors, the GHRH receptor and the ghrelin/GHS receptor, so combining them produces a synergistic, larger growth-hormone pulse than either peptide alone.

What does 'no DAC' mean?

No DAC (also called Mod GRF 1-29) lacks the Drug Affinity Complex that extends half-life, so it has a short action that preserves natural pulsatile GH release rather than a continuous bleed.

Is this blend approved for human use?

No. Both peptides are unapproved research compounds sold strictly for laboratory study.

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Growth Hormone Secretagogues

Research Chemical

CJC-1295 (No DAC) / GHRP-2 Blend

Also known as: CJC-1295 & GHRP-2, CJC-1295 No DAC + GHRP-2 Blend, Mod GRF 1-29 & GHRP-2

This blend pairs CJC-1295 without DAC (Mod GRF 1-29), a GHRH analog, with GHRP-2, a growth hormone secretagogue, to synergistically stimulate pulsatile growth hormone release. Both are unapproved research peptides.

Mechanism of Action

CJC-1295 without DAC is a modified GHRH(1-29) analog that binds the pituitary GHRH receptor to amplify the amplitude of natural growth-hormone pulses. GHRP-2 is a synthetic ghrelin-mimetic that activates the growth-hormone-secretagogue receptor (GHS-R1a), triggering GH release through a distinct pathway and partially suppressing somatostatin tone. Combining a GHRH analog with a GHRP produces a synergistic, greater-than-additive GH pulse because the two receptors act on complementary signaling cascades. The no-DAC form has a short half-life that preserves pulsatile, physiologic GH and downstream IGF-1 release.

Half-life: Short for both components: roughly 30 minutes for CJC-1295 no DAC and about 15-30 minutes for GHRP-2
Administration Routes: subcutaneous
Research Status: Research Chemical