GHRP-2
Also known as: GHRP-2, Pralmorelin
A growth hormone releasing peptide that strongly stimulates GH secretion via the ghrelin receptor. More potent than GHRP-6 with somewhat less appetite stimulation.
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Mechanism of Action
GHRP-2 is a synthetic hexapeptide agonist of the ghrelin/GHS-R1a receptor that triggers a robust pulse of growth hormone from the pituitary. It also modestly stimulates appetite and can transiently raise prolactin, ACTH, and cortisol at higher doses. Its potency makes it effective at amplifying GH output, particularly when combined with a GHRH analog that acts on a separate receptor pathway.
- Half-life
- Approximately 30-45 minutes
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Strong, reliable GH pulse induction
- Supports lean mass and recovery
- Less appetite stimulation than GHRP-6
- Synergistic with GHRH analogs
- May aid sleep and tissue repair
Potential Side Effects
- Increased appetite (less than GHRP-6 but present)
- Transient rises in cortisol and prolactin at higher doses
- Water retention and tingling
- Flushing or head-rush after dosing
Common Dosing
Research literature references ~100-300 mcg per dose, 1-3 times daily, often combined with a GHRH analog and timed to natural GH pulses. Educational reference only.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active malignancy
- Uncontrolled diabetes
- Pregnancy or breastfeeding
- Not approved for human therapeutic use
CJC-1295
A long-acting growth hormone releasing hormone (GHRH) analog that stimulates the pituitary to produce more growth hormone. Often paired with a ghrelin mimetic for synergistic GH release.
Sermorelin
A GHRH analog comprising the first 29 amino acids of growth hormone releasing hormone, historically used to assess and stimulate pituitary GH output. A gentler, physiologic GH peptide.
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Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH
1997
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Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men
2005
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A five day treatment with daily subcutaneous injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-I secretion in healthy young men
1998
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Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism
2008