Sermorelin
Also known as: Sermorelin, GRF 1-29
A GHRH analog comprising the first 29 amino acids of growth hormone releasing hormone, historically used to assess and stimulate pituitary GH output. A gentler, physiologic GH peptide.
Last updated
Mechanism of Action
Sermorelin is a truncated GHRH (1-29) analog that binds the pituitary GHRH receptor, stimulating the synthesis and pulsatile release of endogenous growth hormone. Because it works upstream on the pituitary rather than supplying exogenous GH, it preserves natural feedback regulation. Its short half-life produces a brief, physiologic GH pulse, and it synergizes with ghrelin mimetics.
- Half-life
- Approximately 10-20 minutes
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Stimulates the body's own GH production
- Preserves natural GH feedback and pulsatility
- Supports recovery, body composition, and sleep
- Historically used in pediatric GH-deficiency diagnostics
- Synergistic with ghrelin mimetics
Potential Side Effects
- Injection-site flushing or pain
- Headache or dizziness
- Transient flushing of the face
- Possible water retention
Common Dosing
Research and historical clinical references cite ~100-500 mcg per dose, typically once daily before bed to align with nocturnal GH release. Educational reference only.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active malignancy
- Hypersensitivity to sermorelin
- Pregnancy or breastfeeding
- Use only under research conditions
Ipamorelin
A selective ghrelin receptor agonist (growth hormone secretagogue) prized for stimulating GH release with minimal effect on cortisol or prolactin. Considered one of the gentler GH peptides.
GHRP-2
A growth hormone releasing peptide that strongly stimulates GH secretion via the ghrelin receptor. More potent than GHRP-6 with somewhat less appetite stimulation.
GHRP-6
An early growth hormone releasing peptide best known for strong GH stimulation alongside a pronounced increase in appetite via ghrelin signaling.
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Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency
1999
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Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men
1997
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Long-term therapy with a single daily subcutaneous dose of growth hormone releasing hormone (1-29) in prepubertal growth hormone deficient children. Venezuelan Collaborative Study Group
1994