How is sermorelin different from synthetic HGH?

Sermorelin stimulates the pituitary to release its own growth hormone, preserving natural feedback loops, whereas synthetic HGH supplies the hormone directly and bypasses that regulation.

When is sermorelin typically dosed?

Its short half-life means it is usually studied as a single dose before sleep to reinforce the body's natural nighttime GH pulse.

← All peptides

Growth Hormone Secretagogues

Research Chemical

Sermorelin

Also known as: Sermorelin, GRF 1-29

A GHRH analog comprising the first 29 amino acids of growth hormone releasing hormone, historically used to assess and stimulate pituitary GH output. A gentler, physiologic GH peptide.

Mechanism of Action

Sermorelin is a truncated GHRH (1-29) analog that binds the pituitary GHRH receptor, stimulating the synthesis and pulsatile release of endogenous growth hormone. Because it works upstream on the pituitary rather than supplying exogenous GH, it preserves natural feedback regulation. Its short half-life produces a brief, physiologic GH pulse, and it synergizes with ghrelin mimetics.

Half-life: Approximately 10-20 minutes
Administration Routes: subcutaneous
Research Status: Research Chemical