Testosterone Enanthate
Also known as: Test E, Xyosted
A long-acting injectable testosterone ester used for testosterone replacement therapy. Clinically near-interchangeable with cypionate. Prescription medication.
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Mechanism of Action
An esterified testosterone that is slowly released after injection and cleaved to free testosterone, which activates the androgen receptor. Pharmacokinetics are very similar to cypionate; the enanthate ester gives a comparable multi-day half-life supporting weekly or twice-weekly dosing.
- Half-life
- ~7 days (enanthate ester)
- Administration Routes
- Intramuscular, Subcutaneous
- Research Status
- Clinical
Reported Benefits
- Restores serum testosterone in diagnosed hypogonadism
- Supports libido, mood, energy, lean mass, and bone density
- Stable levels with weekly or split dosing
Potential Side Effects
- Erythrocytosis (elevated hematocrit)
- Estrogenic effects via aromatization
- Testicular atrophy and reduced fertility
- Acne, oily skin
Common Dosing
Reported TRT dosing is typically 100-200 mg per week, frequently split, titrated to labs and symptoms under physician supervision.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Prostate or breast cancer
- Untreated erythrocytosis
- Pregnancy
- Uncontrolled cardiovascular disease — medical supervision required
HCG (Human Chorionic Gonadotropin)
A glycoprotein hormone produced in pregnancy that mimics luteinizing hormone, used clinically to stimulate gonadal function. It is studied to support testosterone production and fertility.
Anastrozole
An aromatase inhibitor used off-label to control estrogen elevation on testosterone therapy. Prescription medication (approved for breast cancer).
Enclomiphene
A selective estrogen receptor modulator (SERM) that raises the body's own testosterone by increasing LH and FSH. Investigational; used off-label.
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The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
1996
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Testosterone dose-response relationships in healthy young men
2001
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Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study
2015
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Post-market safety and efficacy profile of subcutaneous testosterone enanthate-autoinjector: a cohort analysis
2022