Enclomiphene
Also known as: Enclomiphene citrate, trans-clomiphene
A selective estrogen receptor modulator (SERM) that raises the body's own testosterone by increasing LH and FSH. Investigational; used off-label.
Last updated
Mechanism of Action
Enclomiphene is the trans-isomer of clomiphene. It blocks estrogen receptors in the hypothalamus/pituitary, removing negative feedback so the body secretes more LH and FSH, which stimulates endogenous testosterone production while preserving fertility — unlike exogenous testosterone, which suppresses it.
- Half-life
- ~10 hours
- Administration Routes
- Oral
- Research Status
- Clinical
Reported Benefits
- Raises endogenous testosterone without exogenous hormone
- Preserves sperm production and testicular function
- Oral; an option for men prioritizing fertility
Potential Side Effects
- Mood changes, irritability
- Visual disturbances (rare, SERM class effect)
- Elevated estradiol in some users
Common Dosing
Reported off-label protocols use a low oral daily or every-other-day dose, titrated to serum testosterone and symptoms. It is investigational and should be used only under medical supervision.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pre-existing visual disorders
- Hormone-sensitive conditions
- Use only under medical supervision
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Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone
2014
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Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement
2016
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Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics
2013
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Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials
2025