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Also known as: Enclomiphene citrate, trans-clomiphene
A selective estrogen receptor modulator (SERM) that raises the body's own testosterone by increasing LH and FSH. Investigational; used off-label.
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Enclomiphene is the trans-isomer of clomiphene. It blocks estrogen receptors in the hypothalamus/pituitary, removing negative feedback so the body secretes more LH and FSH, which stimulates endogenous testosterone production while preserving fertility — unlike exogenous testosterone, which suppresses it.