How is this different from a Sermorelin / GHRP-6 blend?

GHRP-2 is generally considered a more potent GH secretagogue than GHRP-6 and tends to cause less pronounced hunger, though both stimulate appetite to some degree through the ghrelin receptor.

Why pair a GHRH analog with a GHRP?

Sermorelin (a GHRH analog) and GHRP-2 act on separate pituitary receptors, so combining them produces a synergistic GH pulse that is larger than either peptide alone in research models.

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Growth Hormone Secretagogues

Research Chemical

Sermorelin / GHRP-2 Blend

Also known as: Sermorelin & GHRP-2, Sermorelin + GHRP-2 Blend

A research blend pairing the GHRH analog Sermorelin with the growth hormone-releasing peptide GHRP-2. The combination is studied for synergistic stimulation of endogenous growth hormone.

Mechanism of Action

Sermorelin is a 29-amino-acid analog of growth hormone-releasing hormone (GHRH 1-29) that binds the pituitary GHRH receptor to promote synthesis and release of growth hormone. GHRP-2 is a synthetic agonist of the GHS-R1a (ghrelin) receptor that triggers a distinct GH pulse and suppresses somatostatin tone. Because the two peptides act on different receptors, their co-administration produces a synergistic, greater-than-additive GH release while preserving the natural pulsatile pattern of secretion.

Half-life: Mixed: Sermorelin ~10-20 minutes, GHRP-2 ~30-60 minutes
Administration Routes: subcutaneous
Research Status: Research Chemical