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Also known as: Semaglutide, Ozempic, Wegovy, Rybelsus
A long-acting GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and chronic weight management (Wegovy). Among the most effective approved weight-loss therapies.
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Semaglutide is a GLP-1 receptor agonist that mimics the incretin hormone glucagon-like peptide-1, enhancing glucose-dependent insulin secretion and suppressing glucagon. It slows gastric emptying and acts on hypothalamic appetite centers to increase satiety and reduce food intake. Fatty-acid acylation extends its half-life to roughly one week, enabling once-weekly subcutaneous dosing.