Semaglutide vs Tirzepatide
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The key difference
Both are approved once-weekly injections for type 2 diabetes and obesity. Semaglutide activates the GLP-1 receptor; tirzepatide activates both the GIP and GLP-1 receptors. In the SURMOUNT-5 head-to-head trial in adults with obesity, average weight loss at 72 weeks was 20.2% with tirzepatide versus 13.7% with semaglutide.
- Source: Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. (PMID 40353578)
Side by side
- Significant, sustained weight loss in clinical trials
- Improves glycemic control in type 2 diabetes
- Reduces cardiovascular events in high-risk patients
- Increases satiety and reduces appetite
- Substantial weight loss, often exceeding GLP-1-only agents
- Strong improvement in glycemic control
- Dual incretin action (GIP + GLP-1)
- Improves lipid and metabolic markers
- Nausea, vomiting, and diarrhea (especially during titration)
- Constipation and abdominal discomfort
- Risk of pancreatitis (uncommon)
- Gallbladder issues with rapid weight loss
- Nausea, vomiting, and diarrhea (especially during titration)
- Decreased appetite and constipation
- Risk of pancreatitis (uncommon)
- Gallbladder issues with rapid weight loss
How Semaglutide works
Semaglutide is a GLP-1 receptor agonist that mimics the incretin hormone glucagon-like peptide-1, enhancing glucose-dependent insulin secretion and suppressing glucagon. It slows gastric emptying and acts on hypothalamic appetite centers to increase satiety and reduce food intake. Fatty-acid acylation extends its half-life to roughly one week, enabling once-weekly subcutaneous dosing.
Full Semaglutide profile →How Tirzepatide works
Tirzepatide is a single peptide that activates both the GIP and GLP-1 incretin receptors. GLP-1 agonism enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite, while GIP agonism is thought to further improve insulin sensitivity and lipid metabolism. This dual incretin action produces robust glycemic and weight effects, with fatty-acid acylation enabling once-weekly dosing.
Full Tirzepatide profile →Dosing shown is what research and community sources report, not a recommendation. For educational and research purposes only; not medical advice. How we source this