← All peptides
Collagen & Skin
Clinical

Tripeptide-10 Citrulline

Also known as: Decorinyl, Lys-Asp-Ile-Cit

Tripeptide-10 citrulline (Decorinyl) is a synthetic decorin-mimicking peptide used in anti-wrinkle skincare. A cosmetic ingredient, not a drug.

Last updated

Mechanism of Action

Despite its INCI name, tripeptide-10 citrulline is a tetrapeptide (Lys-Asp-Ile-citrulline) designed to mimic the collagen-binding site of decorin, a proteoglycan that regulates how collagen fibrils assemble. In supplier in vitro tests it regulated collagen fibrillogenesis and produced thinner, more uniform fibrils, with the aim of improving collagen organization rather than collagen quantity. Human evidence is limited to one small randomized study.

Half-life
Not well established
Administration Routes
Topical
Research Status
Clinical

Reported Benefits

  • Designed to improve collagen fiber organization
  • One small randomized study on skin wrinkle measures
  • Studied alongside acetyl hexapeptide-3 (Argireline)
  • Evidence remains preliminary

Potential Side Effects

  • Mild redness or irritation
  • Contact sensitivity to the formulation
  • Long-term topical safety data are limited

Common Dosing

There is no medical dose: tripeptide-10 citrulline is a cosmetic ingredient used at low concentrations in finished creams and serums, and the formulation is set by the product manufacturer. Follow the product label.

The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.

Contraindications

  • Known sensitivity to the product or its ingredients
  • Broken, infected or inflamed skin
Collagen & Skin
Research Chemical

Acetyl Hexapeptide-3 (Argireline)

Argireline is a topical cosmetic peptide marketed as a needle-free alternative to neuromodulators, used to soften the appearance of expression lines.

Learn More

  • A new decorin-like tetrapeptide for optimal organization of collagen fibres

    2008

    Note: In vitro study by the ingredient's manufacturer.

    View

  • The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study

    2017

    Note: 24 volunteers; includes a tripeptide-10 citrulline-only arm.

    View

No. As of 2026 it is a cosmetic ingredient, and US cosmetics do not need FDA premarket approval; it is not an approved drug for any condition.

Only a little. A 2017 randomized study in 24 volunteers reported improvements in skin roughness measures with tripeptide-10 citrulline, but the study was small and short, and the founding mechanism data come from the manufacturer.

The two target different things: Argireline is marketed to relax expression lines, while tripeptide-10 citrulline targets collagen organization. The 2017 study tested them alone and together but could not establish a clear synergy.

PeptideChat is for educational and research purposes only. Nothing on this site constitutes medical advice. Peptides are sold as research chemicals only and are not intended for human use. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. PeptideChat is an independent educational resource — not a pharmacy, compounding, or 503A/503B outsourcing facility — and does not sell products or provide medical advice.