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Also known as: Tesofensine
Tesofensine is a triple monoamine reuptake inhibitor originally developed for neurodegenerative disease and later investigated as an anti-obesity drug. It produces appetite suppression and notable weight loss in clinical trials. Note: Tesofensine is a small-molecule triple monoamine reuptake inhibitor, not a peptide, but is sold alongside metabolic research compounds.
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Tesofensine inhibits the presynaptic reuptake of dopamine, norepinephrine, and serotonin, raising synaptic concentrations of all three monoamines. The resulting enhancement of dopaminergic and noradrenergic tone in hypothalamic and reward circuits suppresses appetite and may increase resting energy expenditure. Its serotonergic and noradrenergic actions also contribute to satiety signaling and reduced food intake.