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Also known as: Nolvadex, Tamoxifen citrate
A selective estrogen receptor modulator (SERM) used off-label to manage gynecomastia and in post-cycle therapy. Prescription medication (approved for breast cancer).
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Tamoxifen blocks estrogen receptors in breast tissue (acting as an anti-estrogen there) while behaving as an estrogen agonist in bone and liver. At the pituitary it blocks estrogen negative feedback, raising LH and FSH and therefore endogenous testosterone — which is why it is used both to prevent/treat gynecomastia and to restart the HPG axis in post-cycle therapy. It does not lower total estradiol the way an aromatase inhibitor does.