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Also known as: Clomid, Clomiphene citrate
A selective estrogen receptor modulator (SERM) used off-label to raise endogenous testosterone and to restart natural production in post-cycle therapy. Prescription medication (approved for female fertility).
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Clomiphene blocks estrogen receptors at the hypothalamus and pituitary, removing negative feedback so the body secretes more GnRH, LH, and FSH — which raises endogenous testosterone and supports spermatogenesis. It is a mixture of two isomers: enclomiphene (trans, the anti-estrogenic driver) and zuclomiphene (cis, longer-acting and more estrogenic), which is why side-effect profiles differ from pure enclomiphene.