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Also known as: Preg
The upstream 'mother' hormone: a cholesterol-derived precursor to DHEA, progesterone, and downstream steroids, and a neurosteroid. Available OTC as a supplement; use with medical guidance.
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Synthesized from cholesterol, pregnenolone sits at the top of the steroidogenesis pathway and is converted into progesterone, DHEA, and downstream sex and adrenal steroids. It also acts directly as a neurosteroid, modulating GABA and NMDA receptor signaling — the basis for interest in its effects on memory and mood.