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Also known as: Dehydroepiandrosterone
An adrenal prohormone that the body converts into testosterone and estrogen. Available over the counter as a supplement in the US; still a hormone precursor — use with medical guidance.
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DHEA and its sulfate (DHEA-S) are produced by the adrenal glands and act as precursors that peripheral tissues convert into androgens and estrogens. Levels peak in early adulthood and decline with age; supplementation aims to restore the precursor pool, though downstream conversion and clinical benefit vary considerably between individuals.