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Also known as: Melanotan II, MT-2, MT-II
A synthetic melanocortin agonist that stimulates melanin production for tanning, with notable secondary effects on libido and appetite. Non-selective across melanocortin receptors.
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Melanotan II is a cyclic analog of alpha-MSH that non-selectively activates melanocortin receptors, including MC1R (skin pigmentation) and MC4R (libido and appetite). MC1R activation increases eumelanin synthesis in melanocytes, darkening the skin and providing some photoprotection. Its activity at MC4R explains the commonly observed effects on sexual arousal and reduced appetite.