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Also known as: PT-141, Bremelanotide
A melanocortin receptor agonist FDA-approved (as Vyleesi) for hypoactive sexual desire disorder in premenopausal women. Acts centrally on the brain rather than the vascular system.
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PT-141 (bremelanotide) is a cyclic heptapeptide analog of alpha-MSH that activates melanocortin receptors, particularly MC4R, in the central nervous system. Unlike PDE5 inhibitors that work on blood flow, it modulates neural pathways governing sexual desire and arousal. This central mechanism allows it to influence libido directly through hypothalamic signaling.