Secretin (Human, Synthetic)
Also known as: ChiRhoStim, human secretin
A synthetic version of the gut hormone secretin used as a diagnostic agent for pancreatic function and gastrinoma. FDA-approved as ChiRhoStim (2004).
Last updated
Mechanism of Action
Secretin is a 27-amino-acid hormone released by S cells of the duodenum in response to acid. It binds secretin receptors on pancreatic ductal cells, increasing cyclic AMP and driving secretion of bicarbonate-rich fluid. In patients with gastrinoma (Zollinger-Ellison syndrome), secretin paradoxically stimulates gastrin release from tumor cells, which is the basis of the secretin stimulation test. Synthetic human secretin has the same sequence as the native hormone.
- Half-life
- Short (well under an hour, IV)
- Administration Routes
- Intravenous
- Research Status
- Clinical
Reported Benefits
- Approved to aid diagnosis of pancreatic exocrine dysfunction
- Approved to aid diagnosis of gastrinoma (secretin stimulation test)
- Approved to help identify the ampulla of Vater and accessory papilla during ERCP
- Used in secretin-enhanced MRCP to improve pancreatic duct imaging
Potential Side Effects
- Nausea and vomiting
- Flushing
- Abdominal discomfort
- Hypersensitivity reactions (rare)
Common Dosing
Given as a single weight-based intravenous injection by clinicians during a diagnostic test; the dose depends on the test being performed. Dosing is set and supervised by the prescribing clinician.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- The current label lists no contraindications
- Testing is generally deferred during acute pancreatitis
- Proton pump inhibitors and anticholinergics can alter results and may need to be stopped beforehand
No documented stacking partners for Secretin (Human, Synthetic) yet.
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Secretin: historical perspective and current status
2014
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Comparison of biologic porcine secretin, synthetic porcine secretin, and synthetic human secretin in pancreatic function testing
2003
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Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis of Zollinger-Ellison Syndrome
2021