Hexapeptide-9
Also known as: Collaxyl
Hexapeptide-9 is a synthetic collagen-sequence peptide used in anti-aging skincare. It is a cosmetic ingredient, not an FDA-approved drug.
Last updated
Mechanism of Action
Hexapeptide-9 repeats a short sequence found in collagen and is classed as a matrikine, a fragment intended to signal dermal fibroblasts to make more extracellular matrix such as collagen. Like most peptides it penetrates intact skin poorly, and recent work has focused on delivery enhancers and on a cyclized variant designed to be more stable. Most mechanistic data come from supplier or laboratory studies rather than independent human trials of the plain peptide.
- Half-life
- Not well established
- Administration Routes
- Topical
- Research Status
- Research Chemical
Reported Benefits
- Marketed to support collagen production
- Marketed to reduce the look of fine lines
- Laboratory and enhancer-formulation data only
- Independent trials of the plain peptide are lacking
Potential Side Effects
- Mild redness or irritation
- Contact sensitivity to the formulation
- Long-term topical safety data are limited
Common Dosing
There is no medical dose: hexapeptide-9 is a cosmetic ingredient used at low concentrations in finished serums and creams, and the formulation is set by the product manufacturer. Follow the product label.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known sensitivity to the product or its ingredients
- Broken, infected or inflamed skin
No documented stacking partners for Hexapeptide-9 yet.
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Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions
2025
Note: Tests hexapeptide-9 delivered with an ionic-liquid enhancer; co-authored by an ingredient manufacturer.