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Also known as: Dermorphin
Dermorphin is a naturally occurring opioid heptapeptide originally isolated from the skin of South American Phyllomedusa frogs that acts as an extremely potent and selective mu-opioid receptor agonist.
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Dermorphin is a D-amino-acid-containing heptapeptide (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) that binds with very high affinity and selectivity to the mu-opioid receptor (MOR), a Gi/Go-coupled GPCR. Activation inhibits adenylyl cyclase, reduces cAMP, opens inwardly rectifying potassium channels and closes voltage-gated calcium channels, producing potent analgesia. The unnatural D-alanine residue confers resistance to peptidase degradation, giving it analgesic potency reported to be many times greater than morphine on a molar basis.