VIP
Also known as: VIP, Vasoactive Intestinal Peptide
VIP (vasoactive intestinal peptide) is a 28-amino-acid signaling peptide with vasodilatory, anti-inflammatory, and immunoregulatory actions. It is studied intranasally in protocols for chronic inflammatory and biotoxin-related illness.
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Mechanism of Action
VIP binds the G-protein-coupled receptors VPAC1 and VPAC2, raising intracellular cyclic AMP in target cells. This drives smooth-muscle relaxation and vasodilation, particularly in the pulmonary and splanchnic circulations. VIP also exerts broad anti-inflammatory and immunoregulatory effects, shifting cytokine balance toward a regulatory phenotype and supporting mucosal and neural function. Its short circulating half-life has prompted intranasal delivery for sustained central and respiratory exposure in research settings.
- Half-life
- Very short, roughly 1 to 2 minutes in circulation
- Administration Routes
- intranasal, subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Potent vasodilation and pulmonary smooth-muscle relaxation
- Broad anti-inflammatory and immunoregulatory effects
- Investigated in chronic inflammatory response protocols
- May support mucosal and neural function
- Studied for regulation of cytokine balance
Potential Side Effects
- Flushing and lowered blood pressure
- Headache or lightheadedness
- Nasal irritation with intranasal use
- Transient heart-rate changes
- Limited long-term safety data
Common Dosing
For research use only: research protocols have referenced microgram-range intranasal administration; no validated self-dosing regimen exists. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Hypotension or cardiovascular instability
- Pregnancy and breastfeeding
- Known peptide hypersensitivity
Thymulin
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KPV
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VIP
VIP (vasoactive intestinal peptide) is a 28-amino-acid signaling peptide with vasodilatory, anti-inflammatory, and immunoregulatory actions. It is studied intranasally in protocols for chronic inflammatory and biotoxin-related illness.
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Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions
2013
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Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
2003
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Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis
2010
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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNF-alpha production by macrophages: in vitro and in vivo studies
1999