Vialox (Pentapeptide-3V)
Also known as: Vialox, Pentapeptide-3V, Pentapeptide-3
Vialox is a topical pentapeptide marketed as a needle-free muscle-relaxing cosmetic ingredient. It is studied for softening expression lines by reducing local muscle contraction at the skin surface.
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Mechanism of Action
Vialox (pentapeptide-3) acts as a competitive antagonist at the postsynaptic acetylcholine receptor of the neuromuscular junction in the skin. By blocking acetylcholine binding it reduces muscle fiber contraction in the manner of a curare-like, topically applied agent. The resulting decrease in repeated micro-contractions is intended to smooth dynamic expression lines. Its activity is local and reversible, relying on continued application for a sustained cosmetic effect.
- Half-life
- Not systemically relevant; acts locally in topical use
- Administration Routes
- topical
- Research Status
- Research Chemical
Reported Benefits
- Topical relaxation of facial expression lines
- Needle-free smoothing of dynamic wrinkles
- May improve skin surface smoothness
- Complements other anti-aging peptides
- Generally well tolerated in cosmetic use
Potential Side Effects
- Possible mild irritation or tightness
- Rare contact sensitivity
- Transient redness on application
Common Dosing
For research use only: formulated at low cosmetic concentrations in topical serums and creams; no systemic dosing applies. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known sensitivity to peptide cosmetics
- Application to broken or irritated skin
Acetyl Hexapeptide-3 (Argireline)
Argireline is a topical cosmetic peptide marketed as a needle-free alternative to neuromodulators, used to soften the appearance of expression lines.
SNAP-8
SNAP-8 (Acetyl Octapeptide-3) is a topical cosmetic peptide marketed as a needle-free alternative for softening expression lines by reducing muscle contraction at the surface. It is an elongated analog of the Argireline hexapeptide.
Matrixyl
Matrixyl is a palmitoylated pentapeptide (Pal-KTTKS) used topically to stimulate collagen and extracellular matrix synthesis. It is a widely studied cosmetic anti-wrinkle peptide.
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