Triptorelin (GnRH)
Also known as: Triptorelin, GnRH Agonist
Triptorelin is a long-acting synthetic GnRH agonist used clinically to suppress sex-hormone production after an initial flare. It is applied in prostate cancer, endometriosis, precocious puberty, and fertility protocols.
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Mechanism of Action
Triptorelin is a decapeptide GnRH agonist that initially stimulates pituitary release of LH and FSH, producing a transient hormone flare. With continuous receptor occupancy the gonadotrophs become desensitized and downregulated, sharply reducing LH, FSH, and downstream testosterone or estradiol. This reversible medical castration underlies its use in hormone-dependent cancers and conditions. Depot formulations provide sustained receptor stimulation over weeks to months.
- Half-life
- Approximately 3 hours for the peptide; depot forms last weeks
- Administration Routes
- subcutaneous
- Research Status
- Clinical
Reported Benefits
- Profound suppression of sex hormones after initial flare
- Used in hormone-dependent prostate cancer
- Treatment of endometriosis and uterine fibroids
- Management of central precocious puberty
- Pituitary downregulation in fertility protocols
Potential Side Effects
- Initial testosterone or estrogen flare
- Hot flashes and night sweats
- Reduced libido and erectile changes
- Bone density loss with prolonged use
- Mood changes and fatigue
Common Dosing
For research use only: clinical literature references fixed depot doses given every several weeks to months under medical supervision; this is not personal medical advice or a self-dosing recommendation.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known hypersensitivity to GnRH analogs
- Undiagnosed abnormal genital bleeding
- Osteoporosis without bone-protective management
Gonadorelin (GnRH)
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) studied for stimulating the pituitary release of LH and FSH. It is used in fertility research and to assess or support the hypothalamic-pituitary-gonadal axis.
HCG (Human Chorionic Gonadotropin)
A glycoprotein hormone produced in pregnancy that mimics luteinizing hormone, used clinically to stimulate gonadal function. It is studied to support testosterone production and fertility.
Triptorelin (GnRH)
Triptorelin is a long-acting synthetic GnRH agonist used clinically to suppress sex-hormone production after an initial flare. It is applied in prostate cancer, endometriosis, precocious puberty, and fertility protocols.
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Comparative efficacy of triptorelin pamoate and leuprolide acetate in men with advanced prostate cancer
2003
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An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer
2016
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Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial
2015
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Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. French study group of Decapeptyl in Precocious Puberty
1999