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Also known as: Tripeptide-29, Collagen Tripeptide
Tripeptide-29 is a collagen-biomimetic tripeptide used in topical skincare to signal fibroblasts toward collagen production. It is studied for firmness, elasticity, and overall skin matrix support.
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Tripeptide-29 mimics a sequence found in native collagen and acts as a matrikine-style signaling peptide. When applied topically it interacts with dermal fibroblasts to upregulate procollagen synthesis and extracellular matrix deposition. By reinforcing collagen turnover it aims to improve dermal density, tensile strength, and the appearance of fine lines. Its small size is intended to aid penetration into the upper layers of the skin.