Loading peptide…
PeptideChat is for educational and research purposes only. Nothing on this site constitutes medical advice. Peptides are sold as research chemicals only and are not intended for human use. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. PeptideChat is an independent educational resource — not a pharmacy, compounding, or 503A/503B outsourcing facility — and does not sell products or provide medical advice.
Also known as: TRH, Protirelin, Thyrotropin, TRH Thyrotropin, Thyrotropin TRH, Taltirelin
TRH (protirelin) is the tripeptide hypothalamic hormone that triggers pituitary release of TSH and prolactin. It is also studied for neurostimulant, arousal, and mood-related central nervous system effects.
Sign in to rate this peptide.
Thyrotropin-releasing hormone (pyroGlu-His-Pro-NH2) binds TRH receptors on anterior pituitary thyrotrophs, stimulating secretion of thyroid-stimulating hormone and prolactin. Beyond endocrine regulation, TRH acts as a neuromodulator throughout the central nervous system, enhancing cholinergic and dopaminergic tone and promoting arousal and analgesia. It exerts neuroprotective and antidepressant-like effects in experimental models. Its very short half-life has driven development of stabilized analogs such as taltirelin.