TB-500 Fragment (17-23)
Also known as: TB-500 Fragment 17-23, Thymosin Beta-4 Fragment 17-23, TB4 Frag 17-23
TB-500 Fragment 17-23 is a short peptide corresponding to the actin-binding region of thymosin beta-4, studied for tissue repair and regeneration. It represents the core bioactive sequence often credited with TB-500's healing effects.
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Mechanism of Action
Fragment 17-23 contains the LKKTETQ actin-binding motif of thymosin beta-4, which is central to the parent molecule's regulation of actin polymerization. By modulating the G-actin to F-actin equilibrium, the fragment is thought to promote cell migration, angiogenesis, and the recruitment of progenitor cells to sites of injury. It is also studied for downregulating inflammatory signaling and supporting extracellular matrix remodeling during wound healing.
- Half-life
- Short; small fragments are typically cleared within hours
- Administration Routes
- subcutaneous
- Research Status
- Preclinical
Reported Benefits
- Promotes cell migration and tissue repair
- Supports angiogenesis and new blood vessel formation
- May accelerate wound healing in animal models
- Modulates inflammation at injury sites
- Studied for muscle, tendon, and connective tissue recovery
Potential Side Effects
- Limited human safety data
- Possible injection-site reactions
- Transient fatigue or lightheadedness reported anecdotally
- Unknown long-term effects
Common Dosing
No validated human protocols exist; research handling generally mirrors low-milligram TB-500 frameworks scaled to fragment mass. For research use only and not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active malignancy, due to effects on cell migration and angiogenesis
- Pregnancy or breastfeeding
- Known hypersensitivity to thymosin-derived peptides
BPC-157
A synthetic peptide fragment derived from a protein found in gastric juice, studied for its broad tissue-healing and cytoprotective effects. Popular in research for tendon, ligament, muscle, and gut repair.
TB-500
A synthetic version of the active region of Thymosin Beta-4, a naturally occurring peptide that regulates cell migration and tissue repair. Researched for recovery, flexibility, and wound healing.
TB-500 Fragment (1-4)
TB-500 Fragment 1-4 is the N-terminal tetrapeptide (Ac-SDKP) of thymosin beta-4, studied for anti-fibrotic and tissue-protective effects. This fragment is distinct from the actin-binding region and is associated with regulation of fibrosis and inflammation.
GHK-Cu
A naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) widely researched for skin regeneration, collagen synthesis, and wound healing. Common in topical cosmetics.
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Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice
2003
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Biological activities of thymosin beta4 defined by active sites in short peptide sequences
2010
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Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain
2018
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Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
2012