TB-500
Also known as: TB-500, Thymosin Beta-4, TB-4
A synthetic version of the active region of Thymosin Beta-4, a naturally occurring peptide that regulates cell migration and tissue repair. Researched for recovery, flexibility, and wound healing.
Last updated
Mechanism of Action
TB-500 corresponds to the actin-binding domain of Thymosin Beta-4 and regulates actin polymerization, which governs cell migration, proliferation, and differentiation. By sequestering G-actin and promoting cytoskeletal remodeling, it enables cells such as endothelial and stem cells to migrate to sites of injury. It also upregulates genes associated with angiogenesis and downregulates inflammatory cytokines in preclinical models.
- Half-life
- Long acting; effects attributed to systemic distribution over days
- Administration Routes
- subcutaneous, intramuscular
- Research Status
- Research Chemical
Reported Benefits
- Promotes cell migration and tissue regeneration
- Supports angiogenesis and wound closure in animal models
- May improve flexibility and reduce muscle spasm
- Anti-inflammatory effects on injured tissue
- Studied for cardiac and corneal repair in preclinical work
- Systemic distribution, unlike more locally acting peptides
Potential Side Effects
- Injection-site reactions (redness, swelling)
- Possible transient head-rush or lethargy (anecdotal)
- Theoretical concern with tumor angiogenesis
- No long-term human safety data
Common Dosing
Research protocols often cite a loading phase of 2-2.5 mg twice weekly for several weeks, followed by a maintenance dose. Framed as research-literature ranges, not personal advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active or suspected cancer (angiogenic activity)
- Pregnancy or breastfeeding
- Banned by WADA for competitive athletes
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Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development
2004
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Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
2012
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Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice
2003
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Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
2012