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Also known as: Syn-Coll, Palmitoyl Tripeptide-5
Syn-Coll is a topical lipidated tripeptide designed to stimulate collagen synthesis and improve skin firmness and wrinkle appearance.
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Syn-Coll is palmitoyl tripeptide-5, a fatty-acid-conjugated peptide whose sequence mimics a region of thrombospondin-1 that activates latent transforming growth factor beta (TGF-beta). By promoting TGF-beta activation in the dermis, it stimulates fibroblasts to increase synthesis of type I collagen and other matrix proteins. The palmitoyl tail aids penetration of the stratum corneum so the signal peptide can reach dermal fibroblasts. The result is improved dermal density and a reduction in the appearance of fine lines.