Syn-Coll (Palmitoyl Tripeptide-5)
Also known as: Syn-Coll, Palmitoyl Tripeptide-5
Syn-Coll is a topical lipidated tripeptide designed to stimulate collagen synthesis and improve skin firmness and wrinkle appearance.
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Mechanism of Action
Syn-Coll is palmitoyl tripeptide-5, a fatty-acid-conjugated peptide whose sequence mimics a region of thrombospondin-1 that activates latent transforming growth factor beta (TGF-beta). By promoting TGF-beta activation in the dermis, it stimulates fibroblasts to increase synthesis of type I collagen and other matrix proteins. The palmitoyl tail aids penetration of the stratum corneum so the signal peptide can reach dermal fibroblasts. The result is improved dermal density and a reduction in the appearance of fine lines.
- Half-life
- Not well characterized; acts locally in topical use
- Administration Routes
- topical
- Research Status
- Research Chemical
Reported Benefits
- Stimulates dermal collagen synthesis
- Improves skin firmness and density
- Reduces the appearance of fine lines and wrinkles
- Supports skin smoothness and texture
- Generally well tolerated in topical formulas
Potential Side Effects
- Mild irritation or redness in sensitive skin
- Possible dryness with frequent use
- Rare sensitivity to formulation ingredients
Common Dosing
For research purposes only: typically formulated at about 1-5 percent of supplier solution in topical cosmetic bases, applied once or twice daily. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known sensitivity to the peptide or carrier ingredients
- Application to broken or actively infected skin
Matrixyl
Matrixyl is a palmitoylated pentapeptide (Pal-KTTKS) used topically to stimulate collagen and extracellular matrix synthesis. It is a widely studied cosmetic anti-wrinkle peptide.
GHK (Basic) (Tripeptide-1)
GHK is a naturally occurring human tripeptide (glycyl-L-histidyl-L-lysine) studied for skin remodeling, wound healing, and tissue regeneration. The copper-free 'basic' form is the parent peptide that readily binds copper in tissue.
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Rigin is a palmitoylated tetrapeptide (Palmitoyl Tetrapeptide-7) used in topical cosmetic formulations to reduce signs of skin aging by modulating inflammatory signaling. It is valued for calming reactive, aging skin and supporting a more even tone.
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Note: Tested in a multi-ingredient product, so the result can't be attributed to Syn-Coll (Palmitoyl Tripeptide-5) alone.