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Also known as: Spartan 3, Mod GRF 1-29 + GHRP-6
A growth-hormone-secretagogue blend combining Modified GRF 1-29 (a CJC-1295 without DAC GHRH analog) with GHRP-6 to stimulate pulsatile growth hormone release. It is studied for recovery, body composition, and appetite.
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Modified GRF 1-29 is a stabilized growth-hormone-releasing hormone analog that binds the GHRH receptor on pituitary somatotrophs, increasing the amplitude of growth hormone pulses via cAMP/PKA signaling. GHRP-6 is a growth-hormone-releasing peptide that activates the ghrelin/GHS-R1a receptor, triggering a separate intracellular pathway that amplifies GH release and suppresses somatostatin tone, while also stimulating appetite. Used together, the GHRH analog and the GHS act synergistically through their distinct receptors to produce a larger, more physiologic GH pulse than either alone, which in turn raises IGF-1.