SKF-110679
Also known as: SKF-110679, U-75799
SKF-110679 is an early synthetic growth hormone secretagogue peptide studied for its ability to stimulate growth hormone release. It is a research-grade compound predating modern GHRPs.
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Mechanism of Action
SKF-110679 is a hexapeptide growth hormone secretagogue that acts on the pituitary somatotrophs, functioning as an early agonist at what is now known as the growth hormone secretagogue receptor (GHS-R1a, the ghrelin receptor). Receptor activation triggers phospholipase C signaling, increasing intracellular calcium and stimulating pulsatile growth hormone release. It works largely independently of GHRH and can act synergistically with GHRH signaling. As one of the first-generation secretagogues, it informed later development of compounds such as GHRP-6 and hexarelin.
- Half-life
- Approximately 20-40 minutes (estimated for the secretagogue class)
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Stimulates pulsatile growth hormone secretion in research models
- Acts as a tool compound for GHS-R pharmacology
- May potentiate GHRH-driven GH release
- Useful comparator for studying secretagogue structure-activity
- Investigated for effects on lean tissue signaling pathways
Potential Side Effects
- Possible increased hunger via ghrelin-receptor activity
- Water retention
- Transient changes in cortisol or prolactin
- Injection-site irritation
Common Dosing
No standardized human protocol exists; preclinical work used microgram-per-kilogram ranges by injection. Provided strictly as research-use information and not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Not for human therapeutic use
- Avoid in active malignancy due to GH/IGF-1 stimulation
- Caution with other secretagogues that raise cortisol
Ghrelin Acetate
Ghrelin Acetate is the acetate salt of ghrelin, the endogenous gut-derived hormone that drives hunger and stimulates growth hormone release. It is studied for appetite and GH-axis research.
GHRH (1-29)
GHRH (1-29) is the biologically active N-terminal fragment of human growth hormone-releasing hormone, used in research to stimulate the pituitary to release growth hormone. The synthetic analog of this fragment is also known as sermorelin.
MGF (Mechano Growth Factor)
MGF is a splice variant of IGF-1 produced locally in muscle in response to mechanical loading or damage. It is studied for its role in activating muscle stem cells and supporting tissue repair.
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Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects
1989
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Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
1993
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Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys
1990
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Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites
1989