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Also known as: Rigin, Palmitoyl Tetrapeptide-7
Rigin is a palmitoylated tetrapeptide (Palmitoyl Tetrapeptide-7) used in topical cosmetic formulations to reduce signs of skin aging by modulating inflammatory signaling. It is valued for calming reactive, aging skin and supporting a more even tone.
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Rigin is the tetrapeptide Gly-Gln-Pro-Arg conjugated to palmitic acid, which improves lipophilicity and penetration through the stratum corneum. In skin it is reported to down-regulate excess production of pro-inflammatory cytokines, notably interleukin-6 (IL-6), which rises with chronological and photo-induced aging and contributes to glycation and extracellular-matrix breakdown. By dampening this inflammatory signaling, Palmitoyl Tetrapeptide-7 is theorized to reduce immunosenescence-related dermal damage and help preserve collagen and elastin integrity, improving firmness and tone. It is frequently combined with Palmitoyl Tripeptide-1 (Matrixyl-type peptides) in cosmetic blends.