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Also known as: PTD-DBM
PTD-DBM is a cell-permeable peptide studied in hair-loss research for its ability to activate Wnt/beta-catenin signaling and promote hair follicle neogenesis.
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PTD-DBM links a protein transduction domain (PTD) to a Dishevelled-binding motif (DBM) that disrupts the interaction between CXXC5 and Dishevelled. CXXC5 is a negative feedback regulator of the Wnt/beta-catenin pathway; by blocking its binding to Dishevelled, PTD-DBM relieves this inhibition and restores active Wnt signaling. Elevated beta-catenin activity then drives hair follicle stem cell activation and wound-induced hair follicle neogenesis in animal models.