PTD-DBM
Also known as: PTD-DBM
PTD-DBM is a cell-permeable peptide studied in hair-loss research for its ability to activate Wnt/beta-catenin signaling and promote hair follicle neogenesis.
Last updated
Mechanism of Action
PTD-DBM links a protein transduction domain (PTD) to a Dishevelled-binding motif (DBM) that disrupts the interaction between CXXC5 and Dishevelled. CXXC5 is a negative feedback regulator of the Wnt/beta-catenin pathway; by blocking its binding to Dishevelled, PTD-DBM relieves this inhibition and restores active Wnt signaling. Elevated beta-catenin activity then drives hair follicle stem cell activation and wound-induced hair follicle neogenesis in animal models.
- Half-life
- Not well characterized; topical and locally acting
- Administration Routes
- topical
- Research Status
- Preclinical
Reported Benefits
- Activates Wnt/beta-catenin signaling in research models
- Studied for hair follicle regeneration and neogenesis
- Investigated for promoting hair regrowth
- Often paired with valproic acid in studies for additive Wnt activation
- Explored for wound-induced follicle formation
Potential Side Effects
- Possible local skin irritation
- Limited human safety data
- Theoretical concern with chronic Wnt pathway activation
- Unknown long-term effects
Common Dosing
For research use only; preclinical work applies it topically to the scalp/skin, frequently combined with valproic acid as a Wnt enhancer. No validated human dosing exists and this is not medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Not for human or clinical use
- Application to broken skin or active skin cancer (Wnt activation concern)
- Pregnancy or breastfeeding
No documented stacking partners for PTD-DBM yet.
- View
Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis
2017
- View
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing
2015
- View
CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2)
2023
- View
Adhesive Hydrogel Patch-Mediated Combination Drug Therapy Induces Regenerative Wound Healing through Reconstruction of Regenerative Microenvironment.
2023