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Also known as: PNC-28
PNC-28 is an experimental p53-derived anticancer peptide closely related to PNC-27, studied for selective membrane disruption of tumor cells. It is a laboratory research compound only, with no approved clinical use.
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PNC-28 combines a p53-derived sequence with a penetratin (Antennapedia) membrane-transduction domain. Like PNC-27, it is reported to target HDM-2 aberrantly present at the cancer cell membrane and to form transmembrane pores that trigger selective necrosis. The cytotoxic effect is thought to be largely transcription-independent and driven by membrane permeabilization. All current data derive from in vitro and animal experiments.