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Also known as: PNC-27
PNC-27 is an experimental anticancer peptide designed to selectively destroy cancer cells by disrupting their membranes while sparing normal cells. It is strictly a laboratory research compound with no approved human use.
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PNC-27 fuses a p53-derived domain (residues that interact with HDM-2/MDM-2) to a membrane-penetrating leader sequence. In cancer cells, HDM-2 is aberrantly expressed at the plasma membrane, and PNC-27 binds it there to form transmembrane pore-like structures that cause selective membrane lysis and necrosis. Because normal cells lack membrane-bound HDM-2, they are reported to be spared in vitro. The mechanism is membrane-targeted and largely independent of the classical p53 transcriptional pathway, and remains confined to cell-culture and animal studies.